Non-angiogenic functions of VEGF in breast cancer.


Journal Article (Review)

This review advances the hypothesis that the function of vascular endothelial growth factor (VEGF) in breast cancer is not limited to angiogenesis, and that VEGF signaling in breast carcinoma cells is important for the ability of these cells to evade apoptosis and progress towards invasive and metastatic disease. In other terms, VEGF signaling provides a selective advantage for the survival and dissemination of breast carcinoma cells that may be independent of angiogenesis. The key component of this hypothesis is that breast carcinoma cells express specific VEGF receptors and that these receptors respond to autocrine VEGF, resulting in the activation of signaling pathways that impede apoptosis and promote cell migration. A related hypothesis, which is developed in this review, is that the alpha6beta4 integrin, which has been implicated in the survival and motility of breast cancer cells, can stimulate the translation of VEGF mRNA and, consequently, autocrine VEGF signaling. These findings imply that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also target tumor cells directly.

Full Text

Duke Authors

Cited Authors

  • Mercurio, AM; Lipscomb, EA; Bachelder, RE

Published Date

  • October 2005

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 283 - 290

PubMed ID

  • 16924371

Pubmed Central ID

  • 16924371

International Standard Serial Number (ISSN)

  • 1083-3021

Digital Object Identifier (DOI)

  • 10.1007/s10911-006-9001-9


  • eng

Conference Location

  • United States