A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.

Journal Article

Antibodies are natural nanomaterials and have been widely used for targeted cell labeling. However, the applications of antibodies are often limited by their large size and instability. The purpose of this study is to develop a new type of multifunctional nanomaterial that is comprised of a nucleic acid aptamer and a dendrimer, both of which are stable. This nanomaterial is approximately 8 nm in size. Moreover, it could not only carry multiple signal molecules, but also bind to target cancer cells with high affinity and specificity. This sub-10 nm multifunctional nanomaterial is expected to be useful in basic biomedical research and clinical medicine.

Full Text

Duke Authors

Cited Authors

  • Zhou, J; Soontornworajit, B; Martin, J; Sullenger, BA; Gilboa, E; Wang, Y

Published Date

  • September 9, 2009

Published In

Volume / Issue

  • 9 / 9

Start / End Page

  • 831 - 835

PubMed ID

  • 19434675

Electronic International Standard Serial Number (EISSN)

  • 1616-5195

Digital Object Identifier (DOI)

  • 10.1002/mabi.200900046

Language

  • eng

Conference Location

  • Germany