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The impact of pre-radiotherapy surgery on radiation-induced lung injury.

Publication ,  Journal Article
Kocak, Z; Yu, X; Zhou, SM; D'Amico, TA; Hollis, D; Kahn, D; Tisch, A; Shafman, TD; Marks, LB
Published in: Clin Oncol (R Coll Radiol)
June 2005

AIMS: The use of postoperative radiation therapy (PORT) is predicated by an assessment of the potential benefits and risks, including radiation-induced lung injury. In this study, the risk of radiation-induced lung injury is assessed in patients who received PORT, and compared with a group of patients who received radiation without prior surgery, to determine if surgery increases the risk of radiation pneumonitis. MATERIALS AND METHODS: From 1991 to 2003, 251 patients with lung cancer were enrolled into a prospective study to assess radiation-induced lung injury. All patients received three-dimensional-planned, external-beam radiotherapy. One hundred and seventy-seven patients with over 6-months follow-up were eligible. For the current analysis, 49 patients (28%) had surgical intervention before radiotherapy. The rates of Grade 2 symptomatic pneumonitis in subgroups, based on the type of pre-radiation surgery, were computed and compared using Fisher's Exact Test. To consider the confounding factor of irradiated lung volume, patient subgroups were further defined on the basis of the mean lung dose. RESULTS: Surgical procedures included pneumonectomy (n=9), lobectomy (n=16), wedge resection (n=8) and exploration without resection (n=16). Radiation-induced lung injury occurred in 33 out of 177 (19%) patients, including 18% of the surgical group and 19% of the non-surgical group. Additionally, no statistically significant difference was found in the rate of radiation-induced lung injury based on the extent of resection. CONCLUSIONS: The incidence of pneumonitis is similar in the surgical and non-surgical groups. Thus, PORT may be safely given to selected patients after surgical exploration or resection.

Duke Scholars

Published In

Clin Oncol (R Coll Radiol)

DOI

ISSN

0936-6555

Publication Date

June 2005

Volume

17

Issue

4

Start / End Page

210 / 216

Location

England

Related Subject Headings

  • Veterinary Sciences
  • Risk Factors
  • Retrospective Studies
  • Radiation Pneumonitis
  • Pneumonectomy
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lung Neoplasms
 

Citation

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Kocak, Z., Yu, X., Zhou, S. M., D’Amico, T. A., Hollis, D., Kahn, D., … Marks, L. B. (2005). The impact of pre-radiotherapy surgery on radiation-induced lung injury. Clin Oncol (R Coll Radiol), 17(4), 210–216. https://doi.org/10.1016/j.clon.2004.11.013
Kocak, Z., X. Yu, S. M. Zhou, T. A. D’Amico, D. Hollis, D. Kahn, A. Tisch, T. D. Shafman, and L. B. Marks. “The impact of pre-radiotherapy surgery on radiation-induced lung injury.Clin Oncol (R Coll Radiol) 17, no. 4 (June 2005): 210–16. https://doi.org/10.1016/j.clon.2004.11.013.
Kocak Z, Yu X, Zhou SM, D’Amico TA, Hollis D, Kahn D, et al. The impact of pre-radiotherapy surgery on radiation-induced lung injury. Clin Oncol (R Coll Radiol). 2005 Jun;17(4):210–6.
Kocak, Z., et al. “The impact of pre-radiotherapy surgery on radiation-induced lung injury.Clin Oncol (R Coll Radiol), vol. 17, no. 4, June 2005, pp. 210–16. Pubmed, doi:10.1016/j.clon.2004.11.013.
Kocak Z, Yu X, Zhou SM, D’Amico TA, Hollis D, Kahn D, Tisch A, Shafman TD, Marks LB. The impact of pre-radiotherapy surgery on radiation-induced lung injury. Clin Oncol (R Coll Radiol). 2005 Jun;17(4):210–216.
Journal cover image

Published In

Clin Oncol (R Coll Radiol)

DOI

ISSN

0936-6555

Publication Date

June 2005

Volume

17

Issue

4

Start / End Page

210 / 216

Location

England

Related Subject Headings

  • Veterinary Sciences
  • Risk Factors
  • Retrospective Studies
  • Radiation Pneumonitis
  • Pneumonectomy
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lung Neoplasms