Targeted therapy for non-small cell lung cancer.

Journal Article (Review)

The overall survival for the treatment of lung cancer patients is less than 15%, despite advances in chemotherapy, radiation therapy, and surgery, due to the inability to control metastatic disease. Over the past three decades, the genetics of lung cancer has been progressively delineated. Small molecule drugs or monoclonal antibodies have been developed that target and inactivate specific cancer-related proteins, such as growth factor receptors or their kinases. This article will review the therapeutic implications of molecular changes associated with non-small cell lung cancer and the status of targeted therapies in its treatment.

Full Text

Duke Authors

Cited Authors

  • Toloza, EM; D'Amico, TA

Published Date

  • 2005

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 199 - 204

PubMed ID

  • 16253823

Pubmed Central ID

  • 16253823

International Standard Serial Number (ISSN)

  • 1043-0679

Digital Object Identifier (DOI)

  • 10.1053/j.semtcvs.2005.08.001


  • eng

Conference Location

  • United States