Lung volume reduction surgery for the management of refractory dyspnea in chronic obstructive pulmonary disease.


Journal Article (Review)

PURPOSE OF REVIEW: This review describes the role of lung volume reduction surgery (LVRS) for the management of refractory dyspnea and other debilitating conditions in patients with chronic obstructive pulmonary disease. Recent studies, including a randomized trial comparing LVRS to medical therapy, are analyzed. RECENT FINDINGS: LVRS plus optimal medical therapy is superior to medical therapy alone in treating certain subsets of patients with severe emphysema. In patients with predominantly upper lobe emphysema and low-exercise capacity, LVRS not only improves symptoms of dyspnea and exercise intolerance, but also is associated with improved survival. Furthermore, LVRS has recently been shown to be superior to medical therapy in improving other quality of life parameters, such as nutritional status, sleep quality, and the frequency of chronic obstructive pulmonary disease (COPD) exacerbations in patients with severe emphysema. SUMMARY: LVRS is an effective strategy in the treatment of properly selected patients with COPD, improving survival and quality of life, including exercise tolerance, dyspnea, oxygen requirement and functional status.

Full Text

Duke Authors

Cited Authors

  • Shah, AA; D'Amico, TA

Published Date

  • June 2009

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 107 - 111

PubMed ID

  • 19436210

Pubmed Central ID

  • 19436210

Electronic International Standard Serial Number (EISSN)

  • 1751-4266

Digital Object Identifier (DOI)

  • 10.1097/SPC.0b013e32832ad5e1


  • eng

Conference Location

  • United States