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Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.

Publication ,  Journal Article
White, KL; Sellers, TA; Fridley, BL; Vierkant, RA; Phelan, CM; Tsai, Y-Y; Kalli, KR; Berchuck, A; Iversen, ES; Hartmann, LC; Liebow, M ...
Published in: Twin Res Hum Genet
February 2010

The chromosome 8q24 region (specifically, 8q24.21.a) is known to harbor variants associated with risk of breast, colorectal, prostate, and bladder cancers. In 2008, variants rs10505477 and rs6983267 in this region were associated with increased risk of invasive ovarian cancer (p < 0.01); however, three subsequent ovarian cancer reports of 8q24 variants were null. Here, we used a multi-site case-control study of 940 ovarian cancer cases and 1,041 controls to evaluate associations between these and other single-nucleotide polymorphisms (SNPs) in this 8q24 region, as well as in the 9p24 colorectal cancer associated-region (specifically, 9p24.1.b). A total of 35 SNPs from previous reports and additional tagging SNPs were assessed using an Illumina GoldenGate array and analyzed using logistic regression models, adjusting for population structure and other potential confounders. We observed no association between genotypes and risk of ovarian cancer considering all cases, invasive cases, or invasive serous cases. For example, at 8q24 SNPs rs10505477 and rs6983267, analyses yielded per-allele invasive cancer odds ratios of 0.95 (95% confidence interval (CI) 0.82-1.09, p trend 0.46) and 0.97 (95% CI 0.84-1.12, p trend 0.69), respectively. Analyses using an approach identical to that of the first positive 8q24 report also yielded no association with risk of ovarian cancer. In the 9p24 region, no SNPs were associated with risk of ovarian cancer overall or with invasive or invasive serous disease (all p values > 0.10). These results indicate that the SNPs studied here are not related to risk of this gynecologic malignancy and that the site-specific nature of 8q24.21.a associations may not include ovarian cancer.

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Published In

Twin Res Hum Genet

DOI

ISSN

1832-4274

Publication Date

February 2010

Volume

13

Issue

1

Start / End Page

43 / 56

Location

England

Related Subject Headings

  • Risk Factors
  • Ovarian Neoplasms
  • Middle Aged
  • Logistic Models
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Variation
  • Female
 

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White, K. L., Sellers, T. A., Fridley, B. L., Vierkant, R. A., Phelan, C. M., Tsai, Y.-Y., … Goode, E. L. (2010). Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. Twin Res Hum Genet, 13(1), 43–56. https://doi.org/10.1375/twin.13.1.43
White, Kristin L., Thomas A. Sellers, Brooke L. Fridley, Robert A. Vierkant, Catherine M. Phelan, Ya-Yu Tsai, Kimberly R. Kalli, et al. “Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.Twin Res Hum Genet 13, no. 1 (February 2010): 43–56. https://doi.org/10.1375/twin.13.1.43.
White KL, Sellers TA, Fridley BL, Vierkant RA, Phelan CM, Tsai Y-Y, et al. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. Twin Res Hum Genet. 2010 Feb;13(1):43–56.
White, Kristin L., et al. “Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.Twin Res Hum Genet, vol. 13, no. 1, Feb. 2010, pp. 43–56. Pubmed, doi:10.1375/twin.13.1.43.
White KL, Sellers TA, Fridley BL, Vierkant RA, Phelan CM, Tsai Y-Y, Kalli KR, Berchuck A, Iversen ES, Hartmann LC, Liebow M, Armasu S, Fredericksen Z, Larson MC, Duggan D, Couch FJ, Schildkraut JM, Cunningham JM, Goode EL. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. Twin Res Hum Genet. 2010 Feb;13(1):43–56.
Journal cover image

Published In

Twin Res Hum Genet

DOI

ISSN

1832-4274

Publication Date

February 2010

Volume

13

Issue

1

Start / End Page

43 / 56

Location

England

Related Subject Headings

  • Risk Factors
  • Ovarian Neoplasms
  • Middle Aged
  • Logistic Models
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Variation
  • Female