Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.

Published

Journal Article

Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

Full Text

Duke Authors

Cited Authors

  • Phelan, CM; Tsai, Y-Y; Goode, EL; Vierkant, RA; Fridley, BL; Beesley, J; Chen, XQ; Webb, PM; Chanock, S; Cramer, DW; Moysich, K; Edwards, RP; Chang-Claude, J; Garcia-Closas, M; Yang, H; Wang-Gohrke, S; Hein, R; Green, AC; Lissowska, J; Carney, ME; Lurie, G; Wilkens, LR; Ness, RB; Pearce, CL; Wu, AH; Van Den Berg, DJ; Stram, DO; Terry, KL; Whiteman, DC; Whittemore, AS; DiCioccio, RA; McGuire, V; Doherty, JA; Rossing, MA; Anton-Culver, H; Ziogas, A; Hogdall, C; Hogdall, E; Krüger Kjaer, S; Blaakaer, J; Quaye, L; Ramus, SJ; Jacobs, I; Song, H; Pharoah, PDP; Iversen, ES; Marks, JR; Pike, MC; Gayther, SA; Cunningham, JM; Goodman, MT; Schildkraut, JM; Chenevix-Trench, G; Berchuck, A; Sellers, TA; Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer), ; Australian Ovarian Cancer Study Group,

Published Date

  • February 2010

Published In

Volume / Issue

  • 19 / 2

Start / End Page

  • 600 - 604

PubMed ID

  • 20142253

Pubmed Central ID

  • 20142253

Electronic International Standard Serial Number (EISSN)

  • 1538-7755

International Standard Serial Number (ISSN)

  • 1055-9965

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-09-0861

Language

  • eng