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A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Publication ,  Journal Article
Song, H; Ramus, SJ; Tyrer, J; Bolton, KL; Gentry-Maharaj, A; Wozniak, E; Anton-Culver, H; Chang-Claude, J; Cramer, DW; DiCioccio, R; Dörk, T ...
Published in: Nat Genet
September 2009

Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P < 10(-8)). The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21)).

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

September 2009

Volume

41

Issue

9

Start / End Page

996 / 1000

Location

United States

Related Subject Headings

  • White People
  • United States
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Odds Ratio
  • Molecular Sequence Data
  • Linkage Disequilibrium
  • Humans
  • Homozygote
 

Citation

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Song, H., Ramus, S. J., Tyrer, J., Bolton, K. L., Gentry-Maharaj, A., Wozniak, E., … Gayther, S. A. (2009). A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet, 41(9), 996–1000. https://doi.org/10.1038/ng.424
Song, Honglin, Susan J. Ramus, Jonathan Tyrer, Kelly L. Bolton, Aleksandra Gentry-Maharaj, Eva Wozniak, Hoda Anton-Culver, et al. “A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.Nat Genet 41, no. 9 (September 2009): 996–1000. https://doi.org/10.1038/ng.424.
Song H, Ramus SJ, Tyrer J, Bolton KL, Gentry-Maharaj A, Wozniak E, et al. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet. 2009 Sep;41(9):996–1000.
Song, Honglin, et al. “A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.Nat Genet, vol. 41, no. 9, Sept. 2009, pp. 996–1000. Pubmed, doi:10.1038/ng.424.
Song H, Ramus SJ, Tyrer J, Bolton KL, Gentry-Maharaj A, Wozniak E, Anton-Culver H, Chang-Claude J, Cramer DW, DiCioccio R, Dörk T, Goode EL, Goodman MT, Schildkraut JM, Sellers T, Baglietto L, Beckmann MW, Beesley J, Blaakaer J, Carney ME, Chanock S, Chen Z, Cunningham JM, Dicks E, Doherty JA, Dürst M, Ekici AB, Fenstermacher D, Fridley BL, Giles G, Gore ME, De Vivo I, Hillemanns P, Hogdall C, Hogdall E, Iversen ES, Jacobs IJ, Jakubowska A, Li D, Lissowska J, Lubiński J, Lurie G, McGuire V, McLaughlin J, Medrek K, Moorman PG, Moysich K, Narod S, Phelan C, Pye C, Risch H, Runnebaum IB, Severi G, Southey M, Stram DO, Thiel FC, Terry KL, Tsai Y-Y, Tworoger SS, Van Den Berg DJ, Vierkant RA, Wang-Gohrke S, Webb PM, Wilkens LR, Wu AH, Yang H, Brewster W, Ziogas A, Australian Cancer (Ovarian) Study, Australian Ovarian Cancer Study Group, Ovarian Cancer Association Consortium, Houlston R, Tomlinson I, Whittemore AS, Rossing MA, Ponder BAJ, Pearce CL, Ness RB, Menon U, Kjaer SK, Gronwald J, Garcia-Closas M, Fasching PA, Easton DF, Chenevix-Trench G, Berchuck A, Pharoah PDP, Gayther SA. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet. 2009 Sep;41(9):996–1000.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

September 2009

Volume

41

Issue

9

Start / End Page

996 / 1000

Location

United States

Related Subject Headings

  • White People
  • United States
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Odds Ratio
  • Molecular Sequence Data
  • Linkage Disequilibrium
  • Humans
  • Homozygote