A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

Published

Journal Article

Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P < 10(-8)). The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21)).

Full Text

Duke Authors

Cited Authors

  • Song, H; Ramus, SJ; Tyrer, J; Bolton, KL; Gentry-Maharaj, A; Wozniak, E; Anton-Culver, H; Chang-Claude, J; Cramer, DW; DiCioccio, R; Dörk, T; Goode, EL; Goodman, MT; Schildkraut, JM; Sellers, T; Baglietto, L; Beckmann, MW; Beesley, J; Blaakaer, J; Carney, ME; Chanock, S; Chen, Z; Cunningham, JM; Dicks, E; Doherty, JA; Dürst, M; Ekici, AB; Fenstermacher, D; Fridley, BL; Giles, G; Gore, ME; De Vivo, I; Hillemanns, P; Hogdall, C; Hogdall, E; Iversen, ES; Jacobs, IJ; Jakubowska, A; Li, D; Lissowska, J; LubiƄski, J; Lurie, G; McGuire, V; McLaughlin, J; Medrek, K; Moorman, PG; Moysich, K; Narod, S; Phelan, C; Pye, C; Risch, H; Runnebaum, IB; Severi, G; Southey, M; Stram, DO; Thiel, FC; Terry, KL; Tsai, Y-Y; Tworoger, SS; Van Den Berg, DJ; Vierkant, RA; Wang-Gohrke, S; Webb, PM; Wilkens, LR; Wu, AH; Yang, H; Brewster, W; Ziogas, A; Australian Cancer (Ovarian) Study, ; Australian Ovarian Cancer Study Group, ; Ovarian Cancer Association Consortium, ; Houlston, R; Tomlinson, I; Whittemore, AS; Rossing, MA; Ponder, BAJ; Pearce, CL; Ness, RB; Menon, U; Kjaer, SK; Gronwald, J; Garcia-Closas, M; Fasching, PA; Easton, DF; Chenevix-Trench, G; Berchuck, A; Pharoah, PDP; Gayther, SA

Published Date

  • September 2009

Published In

Volume / Issue

  • 41 / 9

Start / End Page

  • 996 - 1000

PubMed ID

  • 19648919

Pubmed Central ID

  • 19648919

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.424

Language

  • eng

Conference Location

  • United States