In vivo selection of tumor-targeting RNA motifs.

Journal Article (Journal Article)

In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.

Full Text

Duke Authors

Cited Authors

  • Mi, J; Liu, Y; Rabbani, ZN; Yang, Z; Urban, JH; Sullenger, BA; Clary, BM

Published Date

  • January 2010

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 22 - 24

PubMed ID

  • 19946274

Pubmed Central ID

  • PMC2795795

Electronic International Standard Serial Number (EISSN)

  • 1552-4469

Digital Object Identifier (DOI)

  • 10.1038/nchembio.277

Language

  • eng

Conference Location

  • United States