Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6.

Published

Journal Article

The C2H2 zinc finger protein family is one of the largest families of transcription factors. We identified a novel BTB/POZ zinc finger gene from human dendritic cells (DC), which encodes a 733-residue protein with a BTB/POZ domain at the N-terminal and 4 C2H2 zinc fingers at C-terminal. It was designated dendritic cell-derived BTB/POZ zinc finger (DPZF). DPZF protein shares closest homology to BCL-6, with the highest homology present in the BTB/POZ and zinc finger domains. Like BCL-6, DPZF gene is localized on chromosome 3. It is widely expressed in hematopoietic tissues, including DC, monocytes, B cells, and T cells. DPZF protein expression is detectable in lymphoid neoplasm with a molecular mass of 100 kD, especially in B lymphoma. These indicate that DPZF may be a transcription factor closely related to BCL-6, and may be involved in hematopoiesis, oncogenesis, and immune responses.

Full Text

Cited Authors

  • Zhang, W; Mi, J; Li, N; Sui, L; Wan, T; Zhang, J; Chen, T; Cao, X

Published Date

  • April 2001

Published In

Volume / Issue

  • 282 / 4

Start / End Page

  • 1067 - 1073

PubMed ID

  • 11352661

Pubmed Central ID

  • 11352661

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.2001.4689

Language

  • eng