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Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.

Publication ,  Journal Article
Allen, BW; Stamler, JS; Piantadosi, CA
Published in: Trends Mol Med
October 2009

The protected transport of nitric oxide (NO) by hemoglobin (Hb) links the metabolic activity of working tissue to the regulation of its local blood supply through hypoxic vasodilation. This physiologic mechanism is allosterically coupled to the O(2) saturation of Hb and involves the covalent binding of NO to a cysteine residue in the beta-chain of Hb (Cys beta93) to form S-nitrosohemoglobin (SNO-Hb). Subsequent S-transnitrosation, the transfer of NO groups to thiols on the RBC membrane and then in the plasma, preserves NO vasodilator activity for delivery to the vascular endothelium. This SNO-Hb paradigm provides insight into the respiratory cycle and a new therapeutic focus for diseases involving abnormal microcirculatory perfusion. In addition, the formation of S-nitrosothiols in other proteins may regulate an array of physiological functions.

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Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

October 2009

Volume

15

Issue

10

Start / End Page

452 / 460

Location

England

Related Subject Headings

  • Vasodilation
  • S-Nitrosothiols
  • Oxygen
  • Nitrosation
  • Nitric Oxide
  • Immunology
  • Humans
  • Hemoglobins
  • Endothelium, Vascular
  • Cell Hypoxia
 

Citation

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Allen, B. W., Stamler, J. S., & Piantadosi, C. A. (2009). Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med, 15(10), 452–460. https://doi.org/10.1016/j.molmed.2009.08.002
Allen, Barry W., Jonathan S. Stamler, and Claude A. Piantadosi. “Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.Trends Mol Med 15, no. 10 (October 2009): 452–60. https://doi.org/10.1016/j.molmed.2009.08.002.
Allen BW, Stamler JS, Piantadosi CA. Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med. 2009 Oct;15(10):452–60.
Allen, Barry W., et al. “Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.Trends Mol Med, vol. 15, no. 10, Oct. 2009, pp. 452–60. Pubmed, doi:10.1016/j.molmed.2009.08.002.
Allen BW, Stamler JS, Piantadosi CA. Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med. 2009 Oct;15(10):452–460.
Journal cover image

Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

October 2009

Volume

15

Issue

10

Start / End Page

452 / 460

Location

England

Related Subject Headings

  • Vasodilation
  • S-Nitrosothiols
  • Oxygen
  • Nitrosation
  • Nitric Oxide
  • Immunology
  • Humans
  • Hemoglobins
  • Endothelium, Vascular
  • Cell Hypoxia