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End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space.

Publication ,  Journal Article
McSwain, SD; Hamel, DS; Smith, PB; Gentile, MA; Srinivasan, S; Meliones, JN; Cheifetz, IM
Published in: Respir Care
March 2010

BACKGROUND: End-tidal carbon dioxide (P(ETCO(2))) is a surrogate, noninvasive measurement of arterial carbon dioxide (P(aCO(2))), but the clinical applicability of P(ETCO(2)) in the intensive care unit remains unclear. Available research on the relationship between P(ETCO(2)) and P(aCO(2)) has not taken a detailed assessment of physiologic dead space into consideration. We hypothesized that P(ETCO(2)) would reliably predict P(aCO(2)) across all levels of physiologic dead space, provided that the expected P(ETCO(2))-P(aCO(2)) difference is considered. METHODS: Fifty-six mechanically ventilated pediatric patients (0-17 y old, mean weight 19.5 +/- 24.5 kg) were monitored with volumetric capnography. For every arterial blood gas measurement during routine care, we measured P(ETCO(2)) and calculated the ratio of dead space to tidal volume (V(D)/V(T)). We assessed the P(ETCO(2))-P(aCO(2)) relationship with Pearson's correlation coefficient, in 4 V(D)/V(T) ranges. RESULTS: V(D)/V(T) was

Duke Scholars

Published In

Respir Care

ISSN

0020-1324

Publication Date

March 2010

Volume

55

Issue

3

Start / End Page

288 / 293

Location

United States

Related Subject Headings

  • Tidal Volume
  • Retrospective Studies
  • Respiratory System
  • Respiratory Dead Space
  • Respiration, Artificial
  • Intensive Care Units
  • Infant, Newborn
  • Infant
  • Humans
  • Cross-Sectional Studies
 

Citation

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McSwain, S. D., Hamel, D. S., Smith, P. B., Gentile, M. A., Srinivasan, S., Meliones, J. N., & Cheifetz, I. M. (2010). End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space. Respir Care, 55(3), 288–293.
McSwain, S David, Donna S. Hamel, P Brian Smith, Michael A. Gentile, Saumini Srinivasan, Jon N. Meliones, and Ira M. Cheifetz. “End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space.Respir Care 55, no. 3 (March 2010): 288–93.
McSwain SD, Hamel DS, Smith PB, Gentile MA, Srinivasan S, Meliones JN, et al. End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space. Respir Care. 2010 Mar;55(3):288–93.
McSwain, S. David, et al. “End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space.Respir Care, vol. 55, no. 3, Mar. 2010, pp. 288–93.
McSwain SD, Hamel DS, Smith PB, Gentile MA, Srinivasan S, Meliones JN, Cheifetz IM. End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space. Respir Care. 2010 Mar;55(3):288–293.

Published In

Respir Care

ISSN

0020-1324

Publication Date

March 2010

Volume

55

Issue

3

Start / End Page

288 / 293

Location

United States

Related Subject Headings

  • Tidal Volume
  • Retrospective Studies
  • Respiratory System
  • Respiratory Dead Space
  • Respiration, Artificial
  • Intensive Care Units
  • Infant, Newborn
  • Infant
  • Humans
  • Cross-Sectional Studies