Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.
Publication
, Journal Article
Speer, MC; Nye, J; McLone, D; Worley, G; Melvin, EC; Viles, KD; Franklin, A; Drake, C; Mackey, J; George, TM
Published in: Clin Genet
August 1999
Neural tube defects are a common, complex disorder with genetic and environmental components to risk. We investigated the previously reported interaction between homozygosity for the thermolabile variant at the methylenetetrahydrofolate reductase and heterozygosity for the 844ins68 allele at the cystathionine beta-synthase loci in cases with lumbosacral myelomeningocele and their parents. Using control allele frequencies from our sample pooled with those published in the literature, we confirm a marginally significant interaction at these two loci. This finding suggests that additional, larger studies are warranted to investigate this possible interaction in more detail.
Duke Scholars
Published In
Clin Genet
DOI
ISSN
0009-9163
Publication Date
August 1999
Volume
56
Issue
2
Start / End Page
142 / 144
Location
Denmark
Related Subject Headings
- Polymorphism, Genetic
- Oxidoreductases Acting on CH-NH Group Donors
- Odds Ratio
- Neural Tube Defects
- Methylenetetrahydrofolate Reductase (NADPH2)
- Meningomyelocele
- Male
- Humans
- Homozygote
- Genotype
Citation
APA
Chicago
ICMJE
MLA
NLM
Speer, M. C., Nye, J., McLone, D., Worley, G., Melvin, E. C., Viles, K. D., … George, T. M. (1999). Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group. Clin Genet, 56(2), 142–144. https://doi.org/10.1034/j.1399-0004.1999.560208.x
Speer, M. C., J. Nye, D. McLone, G. Worley, E. C. Melvin, K. D. Viles, A. Franklin, C. Drake, J. Mackey, and T. M. George. “Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.” Clin Genet 56, no. 2 (August 1999): 142–44. https://doi.org/10.1034/j.1399-0004.1999.560208.x.
Speer MC, Nye J, McLone D, Worley G, Melvin EC, Viles KD, et al. Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group. Clin Genet. 1999 Aug;56(2):142–4.
Speer, M. C., et al. “Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.” Clin Genet, vol. 56, no. 2, Aug. 1999, pp. 142–44. Pubmed, doi:10.1034/j.1399-0004.1999.560208.x.
Speer MC, Nye J, McLone D, Worley G, Melvin EC, Viles KD, Franklin A, Drake C, Mackey J, George TM. Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group. Clin Genet. 1999 Aug;56(2):142–144.
Published In
Clin Genet
DOI
ISSN
0009-9163
Publication Date
August 1999
Volume
56
Issue
2
Start / End Page
142 / 144
Location
Denmark
Related Subject Headings
- Polymorphism, Genetic
- Oxidoreductases Acting on CH-NH Group Donors
- Odds Ratio
- Neural Tube Defects
- Methylenetetrahydrofolate Reductase (NADPH2)
- Meningomyelocele
- Male
- Humans
- Homozygote
- Genotype