Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group.
Journal Article (Journal Article)
Neural tube defects are a common, complex disorder with genetic and environmental components to risk. We investigated the previously reported interaction between homozygosity for the thermolabile variant at the methylenetetrahydrofolate reductase and heterozygosity for the 844ins68 allele at the cystathionine beta-synthase loci in cases with lumbosacral myelomeningocele and their parents. Using control allele frequencies from our sample pooled with those published in the literature, we confirm a marginally significant interaction at these two loci. This finding suggests that additional, larger studies are warranted to investigate this possible interaction in more detail.
Full Text
Duke Authors
Cited Authors
- Speer, MC; Nye, J; McLone, D; Worley, G; Melvin, EC; Viles, KD; Franklin, A; Drake, C; Mackey, J; George, TM
Published Date
- August 1999
Published In
Volume / Issue
- 56 / 2
Start / End Page
- 142 - 144
PubMed ID
- 10517251
International Standard Serial Number (ISSN)
- 0009-9163
Digital Object Identifier (DOI)
- 10.1034/j.1399-0004.1999.560208.x
Language
- eng
Conference Location
- Denmark