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No association between the APOE gene and autism.

Publication ,  Journal Article
Raiford, KL; Shao, Y; Allen, IC; Martin, ER; Menold, MM; Wright, HH; Abramson, RK; Worley, G; DeLong, GR; Vance, JM; Cuccaro, ML; Gilbert, JR ...
Published in: Am J Med Genet B Neuropsychiatr Genet
February 15, 2004

Autism is a neurodevelopmental disorder characterized by stereotypic and repetitive behavior and interests, together with social and communicative deficiencies. The results of several genomic screens suggest the presence of an autism susceptibility locus on chromosome 19p13.2-q13.4. The apolipoprotein E (APOE) gene on chromosome 19 encodes for a protein, apoE, whose different isoforms (E2, E3, E4) influence neuronal growth. APOE participates in lipid transport and metabolism, repair, growth, and maintenance of axons and myelin during neuronal development. The APOE protein competes with the Reelin protein for VLDL/APOER2 receptor binding. Several studies have reported evidence for an association between autism and the Reelin gene. Based on these data we tested for association between APOE and autism using family-based association methods in a data set of 322 autism families. Three promoter, one intronic, and one 3' UTR single nucleotide polymorphisms (SNPs) in the APOE gene (-491a/t, -427c/t, -219g/t, 113c/g, and 5361c/t) as well as the APOE functional polymorphism (E2, E3, E4) were examined and failed to reveal significant evidence that autism is associated with APOE.

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Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

February 15, 2004

Volume

125B

Issue

1

Start / End Page

57 / 60

Location

United States

Related Subject Headings

  • Reelin Protein
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Autistic Disorder
  • Apolipoproteins E
 

Citation

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Raiford, K. L., Shao, Y., Allen, I. C., Martin, E. R., Menold, M. M., Wright, H. H., … Pericak-Vance, M. A. (2004). No association between the APOE gene and autism. Am J Med Genet B Neuropsychiatr Genet, 125B(1), 57–60. https://doi.org/10.1002/ajmg.b.20104
Raiford, K. L., Y. Shao, I. C. Allen, E. R. Martin, M. M. Menold, H. H. Wright, R. K. Abramson, et al. “No association between the APOE gene and autism.Am J Med Genet B Neuropsychiatr Genet 125B, no. 1 (February 15, 2004): 57–60. https://doi.org/10.1002/ajmg.b.20104.
Raiford KL, Shao Y, Allen IC, Martin ER, Menold MM, Wright HH, et al. No association between the APOE gene and autism. Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15;125B(1):57–60.
Raiford, K. L., et al. “No association between the APOE gene and autism.Am J Med Genet B Neuropsychiatr Genet, vol. 125B, no. 1, Feb. 2004, pp. 57–60. Pubmed, doi:10.1002/ajmg.b.20104.
Raiford KL, Shao Y, Allen IC, Martin ER, Menold MM, Wright HH, Abramson RK, Worley G, DeLong GR, Vance JM, Cuccaro ML, Gilbert JR, Pericak-Vance MA. No association between the APOE gene and autism. Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15;125B(1):57–60.
Journal cover image

Published In

Am J Med Genet B Neuropsychiatr Genet

DOI

ISSN

1552-4841

Publication Date

February 15, 2004

Volume

125B

Issue

1

Start / End Page

57 / 60

Location

United States

Related Subject Headings

  • Reelin Protein
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genetic Predisposition to Disease
  • Female
  • Autistic Disorder
  • Apolipoproteins E