A waiting time problem arising from the study of multi-stage carcinogenesis

Journal Article (Journal Article)

We consider the population genetics problem: how long does it take before some member of the population has m specified mutations? The case m = 2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth. © Institute of Mathematical Statistics, 2009.

Full Text

Duke Authors

Cited Authors

  • Durrett, R; Schmidt, D; Schweinsberg, J

Published Date

  • April 1, 2009

Published In

Volume / Issue

  • 19 / 2

Start / End Page

  • 676 - 718

Electronic International Standard Serial Number (EISSN)

  • 1050-5164

International Standard Serial Number (ISSN)

  • 1050-5164

Digital Object Identifier (DOI)

  • 10.1214/08-AAP559

Citation Source

  • Scopus