Waiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolution.

Published

Journal Article

Results of Nowak and collaborators concerning the onset of cancer due to the inactivation of tumor suppressor genes give the distribution of the time until some individual in a population has experienced two prespecified mutations and the time until this mutant phenotype becomes fixed in the population. In this article we apply these results to obtain insights into regulatory sequence evolution in Drosophila and humans. In particular, we examine the waiting time for a pair of mutations, the first of which inactivates an existing transcription factor binding site and the second of which creates a new one. Consistent with recent experimental observations for Drosophila, we find that a few million years is sufficient, but for humans with a much smaller effective population size, this type of change would take > 100 million years. In addition, we use these results to expose flaws in some of Michael Behe's arguments concerning mathematical limits to Darwinian evolution.

Full Text

Duke Authors

Cited Authors

  • Durrett, R; Schmidt, D

Published Date

  • November 2008

Published In

Volume / Issue

  • 180 / 3

Start / End Page

  • 1501 - 1509

PubMed ID

  • 18791261

Pubmed Central ID

  • 18791261

Electronic International Standard Serial Number (EISSN)

  • 1943-2631

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1534/genetics.107.082610

Language

  • eng