Roles for netrin signaling outside of axon guidance: a view from the worm.

Journal Article (Review;Journal Article)

The Netrin family of extracellular ligands and their receptors were the first identified signaling pathway regulating axon guidance. Subsequent work across model systems has begun to reveal the interactions that take place downstream of Netrin reception to facilitate growth cone migration. Though intensely studied, many aspects of this signaling system remain unclear. Even less understood are the growing number of contexts in which Netrin signaling influences cells beyond axon guidance and even outside the nervous system. Genetic and cell-biological studies in C. elegans have played an instrumental role in identifying critical functions for Netrin ligands in setting up specialized and potentially adhesive membrane-associated domains within a broad range of cell types. Here we review recent literature implicating Netrin or its receptors in morphogenetic processes outside of growth cone regulation with a special focus on studies in C. elegans that suggest cell biological mechanisms for Netrin signaling.

Full Text

Duke Authors

Cited Authors

  • Ziel, JW; Sherwood, DR

Published Date

  • May 2010

Published In

Volume / Issue

  • 239 / 5

Start / End Page

  • 1296 - 1305

PubMed ID

  • 20108323

Pubmed Central ID

  • PMC3072701

Electronic International Standard Serial Number (EISSN)

  • 1097-0177

International Standard Serial Number (ISSN)

  • 1058-8388

Digital Object Identifier (DOI)

  • 10.1002/dvdy.22225


  • eng