Early outcomes following low dose naltrexone enhancement of opioid detoxification.

Journal Article (Journal Article;Multicenter Study)

Although withdrawal severity and treatment completion are the initial focus of opioid detoxification, post-detoxification outcome better defines effective interventions. Very low dose naltrexone (VLNTX) in addition to methadone taper was recently associated with attenuated withdrawal intensity during detoxification. We describe the results of a seven-day follow-up evaluation of 96 subjects who completed inpatient detoxification consisting of the addition of VLNTX (0.125 or 0.250 mg per day) or placebo to methadone taper in a double blind, randomized investigation. Individuals receiving VLNTX during detoxification reported reduced withdrawal and drug use during the first 24 hours after discharge. VLNTX addition was also associated with higher rates of negative drug tests for opioids and cannabis and increased engagement in outpatient treatment after one week. Further studies are needed to test the utility of this approach in easing the transition from detoxification to various follow-up treatment modalities designed to address opioid dependence.

Full Text

Duke Authors

Cited Authors

  • Mannelli, P; Patkar, AA; Peindl, K; Gottheil, E; Wu, L-T; Gorelick, DA

Published Date

  • March 2009

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 109 - 116

PubMed ID

  • 19283561

Pubmed Central ID

  • PMC3190236

Electronic International Standard Serial Number (EISSN)

  • 1521-0391

Digital Object Identifier (DOI)

  • 10.1080/10550490902772785


  • eng

Conference Location

  • England