Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort.

Published

Journal Article

Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. This study was conducted to determine whether IGF-1 polymorphisms are associated with myopia in a large, international dataset of Caucasian high-grade myopia pedigrees.Two hundred sixty-five multiplex families with 1391 subjects participated in the study. IGF-1 genotyping was performed with 13 selected tag single nucleotide polymorphisms (SNPs) using allelic discrimination assays. A family-based pedigree disequilibrium test (PDT) was performed to test for association. Myopia status was defined using sphere (SPH) or spherical equivalent (SE), and analyses assessed the association of (1) high-grade myopia (

Full Text

Duke Authors

Cited Authors

  • Metlapally, R; Ki, C-S; Li, Y-J; Tran-Viet, K-N; Abbott, D; Malecaze, F; Calvas, P; Mackey, DA; Rosenberg, T; Paget, S; Guggenheim, JA; Young, TL

Published Date

  • September 2010

Published In

Volume / Issue

  • 51 / 9

Start / End Page

  • 4476 - 4479

PubMed ID

  • 20435602

Pubmed Central ID

  • 20435602

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

International Standard Serial Number (ISSN)

  • 1552-5783

Digital Object Identifier (DOI)

  • 10.1167/iovs.09-4912

Language

  • eng