Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort.
PURPOSE: Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. This study was conducted to determine whether IGF-1 polymorphisms are associated with myopia in a large, international dataset of Caucasian high-grade myopia pedigrees. METHODS: Two hundred sixty-five multiplex families with 1391 subjects participated in the study. IGF-1 genotyping was performed with 13 selected tag single nucleotide polymorphisms (SNPs) using allelic discrimination assays. A family-based pedigree disequilibrium test (PDT) was performed to test for association. Myopia status was defined using sphere (SPH) or spherical equivalent (SE), and analyses assessed the association of (1) high-grade myopia (
Metlapally, R; Ki, C-S; Li, Y-J; Tran-Viet, K-N; Abbott, D; Malecaze, F; Calvas, P; Mackey, DA; Rosenberg, T; Paget, S; Guggenheim, JA; Young, TL
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