Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.
Publication
, Journal Article
Di, C; Liao, S; Adamson, DC; Parrett, TJ; Broderick, DK; Shi, Q; Lengauer, C; Cummins, JM; Velculescu, VE; Fults, DW; McLendon, RE; Bigner, DD; Yan, H
Published in: Cancer Res
February 1, 2005
Through digital karyotyping of permanent medulloblastoma cell lines, we found that the homeobox gene OTX2 was amplified more than 10-fold in three cell lines. Gene expression analyses showed that OTX2 transcripts were present at high levels in 14 of 15 (93%) medulloblastomas with anaplastic histopathologic features. Knockdown of OTX2 expression by siRNAs inhibited medulloblastoma cell growth in vitro, whereas pharmacologic doses of all-trans retinoic acid repressed OTX2 expression and induced apoptosis only in medulloblastoma cell lines that expressed OTX2. These observations suggest that OTX2 is essential for the pathogenesis of anaplastic medulloblastomas and that these tumors may be amenable to therapy with all-trans-retinoic acid.
Duke Scholars
Published In
Cancer Res
ISSN
0008-5472
Publication Date
February 1, 2005
Volume
65
Issue
3
Start / End Page
919 / 924
Location
United States
Related Subject Headings
- Tretinoin
- Trans-Activators
- RNA, Small Interfering
- Otx Transcription Factors
- Oncology & Carcinogenesis
- Oncogenes
- Nerve Tissue Proteins
- Medulloblastoma
- Humans
- Homeodomain Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Di, C., Liao, S., Adamson, D. C., Parrett, T. J., Broderick, D. K., Shi, Q., … Yan, H. (2005). Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. Cancer Res, 65(3), 919–924.
Di, Chunhui, Shaoxi Liao, David C. Adamson, Timothy J. Parrett, Daniel K. Broderick, Qun Shi, Christoph Lengauer, et al. “Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.” Cancer Res 65, no. 3 (February 1, 2005): 919–24.
Di C, Liao S, Adamson DC, Parrett TJ, Broderick DK, Shi Q, et al. Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. Cancer Res. 2005 Feb 1;65(3):919–24.
Di, Chunhui, et al. “Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.” Cancer Res, vol. 65, no. 3, Feb. 2005, pp. 919–24.
Di C, Liao S, Adamson DC, Parrett TJ, Broderick DK, Shi Q, Lengauer C, Cummins JM, Velculescu VE, Fults DW, McLendon RE, Bigner DD, Yan H. Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. Cancer Res. 2005 Feb 1;65(3):919–924.
Published In
Cancer Res
ISSN
0008-5472
Publication Date
February 1, 2005
Volume
65
Issue
3
Start / End Page
919 / 924
Location
United States
Related Subject Headings
- Tretinoin
- Trans-Activators
- RNA, Small Interfering
- Otx Transcription Factors
- Oncology & Carcinogenesis
- Oncogenes
- Nerve Tissue Proteins
- Medulloblastoma
- Humans
- Homeodomain Proteins