SNPs in CAST are associated with Parkinson disease: a confirmation study.


Journal Article

Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.

Full Text

Duke Authors

Cited Authors

  • Allen, AS; Satten, GA

Published Date

  • June 5, 2010

Published In

Volume / Issue

  • 153B / 4

Start / End Page

  • 973 - 979

PubMed ID

  • 20127884

Pubmed Central ID

  • 20127884

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.31061


  • eng

Conference Location

  • United States