SNPs in CAST are associated with Parkinson disease: a confirmation study.

Journal Article (Journal Article)

Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.

Full Text

Duke Authors

Cited Authors

  • Allen, AS; Satten, GA

Published Date

  • June 5, 2010

Published In

Volume / Issue

  • 153B / 4

Start / End Page

  • 973 - 979

PubMed ID

  • 20127884

Pubmed Central ID

  • PMC3685412

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.31061


  • eng

Conference Location

  • United States