Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.

Published

Journal Article

Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.

Full Text

Duke Authors

Cited Authors

  • Mehta, N; Cunningham, CK; Flynn, P; Pepe, J; Obaro, S; Kapogiannis, BG; Bethel, J; Luzuriaga, K; Adolescent Trials Network for HIV/AIDS Interventions,

Published Date

  • May 2010

Published In

Volume / Issue

  • 28 / 21

Start / End Page

  • 3672 - 3678

PubMed ID

  • 20356567

Pubmed Central ID

  • 20356567

Electronic International Standard Serial Number (EISSN)

  • 1873-2518

International Standard Serial Number (ISSN)

  • 0264-410X

Digital Object Identifier (DOI)

  • 10.1016/j.vaccine.2010.03.022

Language

  • eng