Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells.

Journal Article (Journal Article)

Phosphorodiamidate morpholino oligomers (PMO), which have a neutral chemistry, are extensively being used as tools for selective inhibition of gene expression in cell culture models and are currently in human clinical trials. PMO oligomers possess a unique structure, in which the deoxyribose moiety of DNA is replaced with a six-membered morpholine ring and the charged phosphodiester internucleoside linkages are replaced with neutral phosphorodiamidate linkages. PMO internalization in uptake-permissive cells has been observed to be specific, saturable, and energy-dependent, suggesting a receptor-mediated uptake mechanism. Understanding PMO transport should facilitate the design of more effective synthetic antisense oligomers as therapeutic agents.

Full Text

Duke Authors

Cited Authors

  • Devi, GR

Published Date

  • 2009

Published In

Volume / Issue

  • 542 /

Start / End Page

  • 351 - 361

PubMed ID

  • 19565912

International Standard Serial Number (ISSN)

  • 1064-3745

Digital Object Identifier (DOI)

  • 10.1007/978-1-59745-561-9_19


  • eng

Conference Location

  • United States