The vertebrate primary cilium in development, homeostasis, and disease.


Journal Article (Review)

Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

Full Text

Cited Authors

  • Gerdes, JM; Davis, EE; Katsanis, N

Published Date

  • April 3, 2009

Published In

Volume / Issue

  • 137 / 1

Start / End Page

  • 32 - 45

PubMed ID

  • 19345185

Pubmed Central ID

  • 19345185

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2009.03.023


  • eng

Conference Location

  • United States