The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle.


Journal Article (Review)

Cilia and flagella are found on the surface of a strikingly diverse range of cell types. These intriguing organelles, with their unique and highly adapted protein transport machinery, have been studied extensively in the context of cellular locomotion, sexual reproduction, or fluid propulsion. However, recent studies are beginning to show that in vertebrates particularly, cilia have been recruited to perform additional developmental and homeostatic roles. Here, we review advances in deciphering the functional components of cilia, and we explore emerging trends that implicate ciliary proteins in signal transduction and morphogenetic pathways.

Full Text

Cited Authors

  • Davis, EE; Brueckner, M; Katsanis, N

Published Date

  • July 2006

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 9 - 19

PubMed ID

  • 16824949

Pubmed Central ID

  • 16824949

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2006.06.009


  • eng

Conference Location

  • United States