A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus.

Journal Article (Journal Article)

OBJECTIVE: To develop and propose a standardized battery of neuropsychological tests for the assessment of cognitive functioning of children and adolescents with pediatric systemic lupus erythematosus (SLE). METHODS: A committee of health care professionals involved in the assessment of pediatric SLE patients reviewed the literature to identify cognitive domains most commonly affected in pediatric SLE and in adult SLE. They then reviewed the standardized tests available for children and adolescents that assess the cognitive domains identified. Through a structured consensus formation process, the committee considered the psychometric characteristics and durations of the tests. RESULTS: A test battery was developed that appears suitable to provide a comprehensive assessment of cognitive domains commonly affected by pediatric SLE within a 2.5-hour period. CONCLUSION: It is hoped that the consistent use of this reliable and efficient battery increases the practicality of routine evaluations in pediatric SLE, enabling between-cohort comparisons and facilitating the longitudinal assessment of individual patients over time.

Full Text

Duke Authors

Cited Authors

  • Ross, GS; Zelko, F; Klein-Gitelman, M; Levy, DM; Muscal, E; Schanberg, LE; Anthony, K; Brunner, HI; Childhood Arthritis & Rheumatology Research Alliance Ad-Hoc Neurocognitive Lupus Committee,

Published Date

  • July 2010

Published In

Volume / Issue

  • 62 / 7

Start / End Page

  • 1029 - 1033

PubMed ID

  • 20589693

Pubmed Central ID

  • PMC2936487

Electronic International Standard Serial Number (EISSN)

  • 2151-4658

Digital Object Identifier (DOI)

  • 10.1002/acr.20152


  • eng

Conference Location

  • United States