Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants.

Journal Article (Journal Article)

Atomic force microscopy was used to "fish" for binding reactions between a fibronectin-coated probe (i.e., substrate simulating an implant device) and each of 15 different isolates of Staphylococcus aureus obtained from either patients with an infected cardiac prosthesis (invasive group) or healthy human subjects (control group). There is a strong distinction (p = 0.01) in the binding-force signature observed for the invasive versus control populations. This observation suggests that a microorganism's "force taxonomy" may provide a fundamental and practical indicator of the pathogen-related risk that infections pose to patients with implanted medical devices.

Full Text

Duke Authors

Cited Authors

  • Yongsunthon, R; Fowler, VG; Lower, BH; Vellano, FP; Alexander, E; Reller, LB; Corey, GR; Lower, SK

Published Date

  • February 27, 2007

Published In

Volume / Issue

  • 23 / 5

Start / End Page

  • 2289 - 2292

PubMed ID

  • 17274638

International Standard Serial Number (ISSN)

  • 0743-7463

Digital Object Identifier (DOI)

  • 10.1021/la063117v


  • eng

Conference Location

  • United States