Skip to main content
Journal cover image

Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection.

Publication ,  Journal Article
Fowler, VG; Nelson, CL; McIntyre, LM; Kreiswirth, BN; Monk, A; Archer, GL; Federspiel, J; Naidich, S; Remortel, B; Rude, T; Brown, P; Gill, SR ...
Published in: J Infect Dis
September 1, 2007

BACKGROUND: The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear. METHODS: Three hundred seventy-nine S. aureus isolates (125 methicillin-resistant S. aureus [MRSA] and 254 methicillin-susceptible S. aureus [MSSA]) were genotyped by spa typing and multilocus sequence typing. For MRSA isolates, the staphylococcal chromosomal cassette mec (SCCmec) element was also typed. Three clinical categories were identified: nasal carriage only (n=118), uncomplicated infection (n=104), and bacteremia with hematogenous complications (n=157). RESULTS: By use of eBURST, 18 clonal complexes (CCs) were found in 371 isolates. Eight CCs accounted for 89% of isolates and occurred in all clinical categories. CC5 (P=.0025) and CC30 (P=.0308) exhibited a significant trend toward more frequent hematogenous complications. Isolates within spa types 2 and 16 showed the same significant trend and grouped within CC5 and CC30, respectively. SCCmec II isolates also showed the same significant trend compared with SCCmec IV; 96% were CC5 or CC30. CONCLUSIONS: Although most S. aureus genotypes exhibited the capacity to cause invasive disease, strains within CC5 and CC30 exhibited a significant trend toward increasing levels of hematogenous complications. Isolates within these CCs were also implicated by use of spa and SCCmec typing. The genetic determinants underlying these findings remain to be demonstrated.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

September 1, 2007

Volume

196

Issue

5

Start / End Page

738 / 747

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Nose
  • Middle Aged
  • Microbiology
  • Methicillin Resistance
  • Humans
  • Genotype
  • Child
  • Carrier State
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fowler, V. G., Nelson, C. L., McIntyre, L. M., Kreiswirth, B. N., Monk, A., Archer, G. L., … Gill, S. R. (2007). Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. J Infect Dis, 196(5), 738–747. https://doi.org/10.1086/520088
Fowler, Vance G., Charlotte L. Nelson, Lauren M. McIntyre, Barry N. Kreiswirth, Alastair Monk, Gordon L. Archer, Jerome Federspiel, et al. “Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection.J Infect Dis 196, no. 5 (September 1, 2007): 738–47. https://doi.org/10.1086/520088.
Fowler VG, Nelson CL, McIntyre LM, Kreiswirth BN, Monk A, Archer GL, et al. Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. J Infect Dis. 2007 Sep 1;196(5):738–47.
Fowler, Vance G., et al. “Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection.J Infect Dis, vol. 196, no. 5, Sept. 2007, pp. 738–47. Pubmed, doi:10.1086/520088.
Fowler VG, Nelson CL, McIntyre LM, Kreiswirth BN, Monk A, Archer GL, Federspiel J, Naidich S, Remortel B, Rude T, Brown P, Reller LB, Corey GR, Gill SR. Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. J Infect Dis. 2007 Sep 1;196(5):738–747.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

September 1, 2007

Volume

196

Issue

5

Start / End Page

738 / 747

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Nose
  • Middle Aged
  • Microbiology
  • Methicillin Resistance
  • Humans
  • Genotype
  • Child
  • Carrier State