Ceftaroline: a cephalosporin with expanded Gram-positive activity.

Journal Article (Journal Article;Review)

Infections caused by resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) are now posing a major health risk for patients in hospital and community settings. There is a need to evaluate new antibiotics that would offer reliable clinical efficacy combined with a favorable safety profile for the treatment of such infections. Ceftaroline is a new member of the cephalosporin class of antibiotics with expanded activity against Gram-positive pathogens such as MRSA, vancomycin-intermediate S. aureus, vancomycin-resistant S. aureus and multidrug-resistant Streptococcus pneumoniae, while retaining good activity against common Gram-negative organisms. Phase II and III studies have shown ceftaroline to be an effective and well-tolerated treatment for complicated skin and skin-structure infections compared with standard therapy. Trials are ongoing in the treatment of community-acquired pneumonia.

Full Text

Duke Authors

Cited Authors

  • Kanafani, ZA; Corey, GR

Published Date

  • February 2009

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 25 - 33

PubMed ID

  • 19207097

Electronic International Standard Serial Number (EISSN)

  • 1746-0921

Digital Object Identifier (DOI)

  • 10.2217/17460913.4.1.25


  • eng

Conference Location

  • England