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Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators.

Publication ,  Journal Article
Chamis, AL; Peterson, GE; Cabell, CH; Corey, GR; Sorrentino, RA; Greenfield, RA; Ryan, T; Reller, LB; Fowler, VG
Published in: Circulation
August 28, 2001

BACKGROUND: Although cardiac device infections (CDIs) are a devastating complication of permanent pacemakers or implantable cardioverter-defibrillators, the incidence of CDI in patients with bacteremia is not well defined. The objective of this study was to determine the incidence of CDI among patients with permanent pacemakers or implantable cardioverter-defibrillators who develop Staphylococcus aureus bacteremia (SAB). METHODS AND RESULTS: A cohort of all adult patients with SAB and permanent pacemakers or implantable cardioverter-defibrillators over a 6-year period was evaluated prospectively. The overall incidence of confirmed CDI was 15 of 33 (45.4%). Confirmed CDI occurred in 9 of the 12 patients (75%) with early SAB (<1 year after device placement). Fifteen of 21 patients (71.5%) with late SAB (>/=1 year after device placement) had either confirmed (6 of 21, 28.5%) or possible (9 of 21, 43%) CDI. In 60% of the patients (9 of 15) with confirmed CDI, no local signs or symptoms suggesting generator pocket infection were noted. CONCLUSIONS: The incidence of CDI among patients with SAB and cardiac devices is high. Neither physical examination nor echocardiography can exclude the possibility of CDI. In patients with early SAB, the device is usually involved, and approximately 40% of these patients have obvious clinical signs of cardiac device involvement. Conversely, in patients with late SAB, the cardiac device is rarely the initial source of bacteremia, and there is a paucity of local signs of device involvement. The cardiac device is involved, however, in >/=28% of these patients.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

August 28, 2001

Volume

104

Issue

9

Start / End Page

1029 / 1033

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prosthesis-Related Infections
  • Pacemaker, Artificial
  • Middle Aged
  • Male
  • Humans
  • Female
  • Echocardiography
 

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Chamis, A. L., Peterson, G. E., Cabell, C. H., Corey, G. R., Sorrentino, R. A., Greenfield, R. A., … Fowler, V. G. (2001). Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators. Circulation, 104(9), 1029–1033. https://doi.org/10.1161/hc3401.095097
Chamis, A. L., G. E. Peterson, C. H. Cabell, G. R. Corey, R. A. Sorrentino, R. A. Greenfield, T. Ryan, L. B. Reller, and V. G. Fowler. “Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators.Circulation 104, no. 9 (August 28, 2001): 1029–33. https://doi.org/10.1161/hc3401.095097.
Chamis AL, Peterson GE, Cabell CH, Corey GR, Sorrentino RA, Greenfield RA, et al. Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators. Circulation. 2001 Aug 28;104(9):1029–33.
Chamis, A. L., et al. “Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators.Circulation, vol. 104, no. 9, Aug. 2001, pp. 1029–33. Pubmed, doi:10.1161/hc3401.095097.
Chamis AL, Peterson GE, Cabell CH, Corey GR, Sorrentino RA, Greenfield RA, Ryan T, Reller LB, Fowler VG. Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators. Circulation. 2001 Aug 28;104(9):1029–1033.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

August 28, 2001

Volume

104

Issue

9

Start / End Page

1029 / 1033

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Prosthesis-Related Infections
  • Pacemaker, Artificial
  • Middle Aged
  • Male
  • Humans
  • Female
  • Echocardiography