Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.

Published

Journal Article

Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state.

Full Text

Duke Authors

Cited Authors

  • Milano, CA; Allen, LF; Rockman, HA; Dolber, PC; McMinn, TR; Chien, KR; Johnson, TD; Bond, RA; Lefkowitz, RJ

Published Date

  • April 1994

Published In

Volume / Issue

  • 264 / 5158

Start / End Page

  • 582 - 586

PubMed ID

  • 8160017

Pubmed Central ID

  • 8160017

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.8160017

Language

  • eng