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Clinical experience of a carbohydrate-restricted diet for the metabolic syndrome.

Publication ,  Journal Article
Vernon, MC; Kueser, B; Transue, M; Yates, HE; Yancy, WS; Westman, EC
Published in: Metab Syndr Relat Disord
2004

BACKGROUND: Our objective was to analyze a restricted carbohydrate dietary approach compared to a standard low-fat diet plus medication plan as treatment for weight loss and the metabolic syndrome. METHODS: This was a retrospective analysis of patients attending an outpatient weight and metabolism management program, including periodic individual visits combined with either a carbohydrate-restricted diet (with multivitamin and essential fatty acids supplementation) or low-fat/low-calorie diet + phentermine/fenfluramine. The main outcome measurements were total body weight and fasting serum lipid profiles. Clinical data were maintained on standardized flow sheets. RESULTS: One hundred twenty-two patients had complete baseline and follow-up information. Sixty-six were treated with a carbohydrate-restricted diet without medication, and 56 were treated with a combination of low-fat/low-calorie diet and medication. Weight loss occurred in both groups, but was greater in the medication group: the carbohydrate-restricted group lost a mean of 9.5 kg over 15.0 weeks (0.63 kg/week); the low-fat/low-calorie diet + medication group lost a mean of 14.1 kg over a mean duration of 20.2 weeks (0.70 kg/week), p < 0.01. The carbohydrate-restricted group had a greater reduction in triglycerides (p = 0.02) and triglyceride/HDL ratio (p = 0.01), and a greater increase in HDL (p < 0.001) than the medication group. CONCLUSIONS: In this outpatient program, a carbohydrate-restricted diet and a low-fat/low-calorie diet + medication led to weight loss, but the carbohydrate-restricted diet had a more favorable effect on triglycerides and HDL. Because of the effects on weight, triglycerides, and HDL, a carbohydrate-restricted diet may be useful for the treatment of metabolic syndrome.

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Published In

Metab Syndr Relat Disord

DOI

EISSN

1557-8518

Publication Date

2004

Volume

2

Issue

3

Start / End Page

180 / 186

Location

United States

Related Subject Headings

  • Endocrinology & Metabolism
  • 4206 Public health
  • 3206 Medical biotechnology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
  • 1004 Medical Biotechnology
 

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Vernon, M. C., Kueser, B., Transue, M., Yates, H. E., Yancy, W. S., & Westman, E. C. (2004). Clinical experience of a carbohydrate-restricted diet for the metabolic syndrome. Metab Syndr Relat Disord, 2(3), 180–186. https://doi.org/10.1089/met.2004.2.180
Vernon, Mary C., Brian Kueser, Melissa Transue, Heather E. Yates, William S. Yancy, and Eric C. Westman. “Clinical experience of a carbohydrate-restricted diet for the metabolic syndrome.Metab Syndr Relat Disord 2, no. 3 (2004): 180–86. https://doi.org/10.1089/met.2004.2.180.
Vernon MC, Kueser B, Transue M, Yates HE, Yancy WS, Westman EC. Clinical experience of a carbohydrate-restricted diet for the metabolic syndrome. Metab Syndr Relat Disord. 2004;2(3):180–6.
Vernon, Mary C., et al. “Clinical experience of a carbohydrate-restricted diet for the metabolic syndrome.Metab Syndr Relat Disord, vol. 2, no. 3, 2004, pp. 180–86. Pubmed, doi:10.1089/met.2004.2.180.
Vernon MC, Kueser B, Transue M, Yates HE, Yancy WS, Westman EC. Clinical experience of a carbohydrate-restricted diet for the metabolic syndrome. Metab Syndr Relat Disord. 2004;2(3):180–186.
Journal cover image

Published In

Metab Syndr Relat Disord

DOI

EISSN

1557-8518

Publication Date

2004

Volume

2

Issue

3

Start / End Page

180 / 186

Location

United States

Related Subject Headings

  • Endocrinology & Metabolism
  • 4206 Public health
  • 3206 Medical biotechnology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
  • 1004 Medical Biotechnology