Epigenomics of centromere assembly and function.

Published

Journal Article (Review)

The centromere is a complex chromosomal locus where the kinetochore is formed and microtubules attach during cell division. Centromere identity involves both genomic and sequence-independent (epigenetic) mechanisms. Current models for how centromeres are formed and, conversely, turned off have emerged from studies of unusual or engineered chromosomes, such as neocentromeres, artificial chromosomes, and dicentric chromosomes. Recent studies have highlighted the importance of unique chromatin marked by the histone H3 variant CENP-A, classical chromatin (heterochromatin and euchromatin), and transcription during centromere activation and inactivation. These advances have deepened our view of what defines a centromere and how it behaves in various genomic and chromatin contexts.

Full Text

Duke Authors

Cited Authors

  • Stimpson, KM; Sullivan, BA

Published Date

  • December 2010

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 772 - 780

PubMed ID

  • 20675111

Pubmed Central ID

  • 20675111

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

Digital Object Identifier (DOI)

  • 10.1016/j.ceb.2010.07.002

Language

  • eng

Conference Location

  • England