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Viruses for the treatment of malignant glioma.

Publication ,  Journal Article
Gromeier, M; Wimmer, E
Published in: Curr Opin Mol Ther
October 2001

Viruses have been considered for use as therapeutic agents against cancer, and malignant glioma in particular. Oncolytic viruses were designed to target malignant cells supporting efficient virus replication, or rendered vulnerable to viral destruction due to tumor-specific defects in their defense against virus infection. Other than conventional cancer chemotherapy, viral antineoplastic agents require complex interactions with the host organism to reach their target and to unleash their oncolytic activity. Recent progress in the design and therapeutic application of oncolytic viruses carries the promise to make these agents available for treatment of malignant glioma.

Duke Scholars

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

October 2001

Volume

3

Issue

5

Start / End Page

503 / 508

Location

England

Related Subject Headings

  • Viruses
  • Virus Replication
  • Virulence
  • Tumor Cells, Cultured
  • Humans
  • Glioma
  • Central Nervous System Neoplasms
  • Cell Death
  • Biotechnology
  • 3206 Medical biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gromeier, M., & Wimmer, E. (2001). Viruses for the treatment of malignant glioma. Curr Opin Mol Ther, 3(5), 503–508.
Gromeier, M., and E. Wimmer. “Viruses for the treatment of malignant glioma.Curr Opin Mol Ther 3, no. 5 (October 2001): 503–8.
Gromeier M, Wimmer E. Viruses for the treatment of malignant glioma. Curr Opin Mol Ther. 2001 Oct;3(5):503–8.
Gromeier, M., and E. Wimmer. “Viruses for the treatment of malignant glioma.Curr Opin Mol Ther, vol. 3, no. 5, Oct. 2001, pp. 503–08.
Gromeier M, Wimmer E. Viruses for the treatment of malignant glioma. Curr Opin Mol Ther. 2001 Oct;3(5):503–508.

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

October 2001

Volume

3

Issue

5

Start / End Page

503 / 508

Location

England

Related Subject Headings

  • Viruses
  • Virus Replication
  • Virulence
  • Tumor Cells, Cultured
  • Humans
  • Glioma
  • Central Nervous System Neoplasms
  • Cell Death
  • Biotechnology
  • 3206 Medical biotechnology