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Poliovirus receptor CD155-targeted oncolysis of glioma.

Publication ,  Journal Article
Merrill, MK; Bernhardt, G; Sampson, JH; Wikstrand, CJ; Bigner, DD; Gromeier, M
Published in: Neuro Oncol
July 2004

Cell adhesion molecules of the immunoglobulin superfamily are aberrantly expressed in malignant glioma. Amongst these, the human poliovirus receptor CD155 provides a molecular target for therapeutic intervention with oncolytic poliovirus recombinants. Poliovirus has been genetically modified through insertion of regulatory sequences derived from human rhinovirus type 2 to selectively replicate within and destroy cancerous cells. Efficacious oncolysis mediated by poliovirus derivatives depends on the presence of CD155 in targeted tumors. To prepare oncolytic polioviruses for clinical application, we have developed a series of assays in high-grade malignant glioma (HGL) to characterize CD155 expression levels and susceptibility to oncolytic poliovirus recombinants. Analysis of 6 HGL cases indicates that CD155 is expressed in these tumors and in primary cell lines derived from these tumors. Upregulation of the molecular target CD155 rendered explant cultures of all studied tumors highly susceptible to a prototype oncolytic poliovirus recombinant. Our observations support the clinical application of such agents against HGL.

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Published In

Neuro Oncol

DOI

ISSN

1522-8517

Publication Date

July 2004

Volume

6

Issue

3

Start / End Page

208 / 217

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Spinal Cord
  • Rhinovirus
  • Receptors, Virus
  • Poliovirus
  • Oncology & Carcinogenesis
  • Membrane Proteins
  • Humans
  • Glioma
  • Gene Expression Regulation, Viral
 

Citation

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Merrill, M. K., Bernhardt, G., Sampson, J. H., Wikstrand, C. J., Bigner, D. D., & Gromeier, M. (2004). Poliovirus receptor CD155-targeted oncolysis of glioma. Neuro Oncol, 6(3), 208–217. https://doi.org/10.1215/S1152851703000577
Merrill, Melinda K., Guenter Bernhardt, John H. Sampson, Carol J. Wikstrand, Darell D. Bigner, and Matthias Gromeier. “Poliovirus receptor CD155-targeted oncolysis of glioma.Neuro Oncol 6, no. 3 (July 2004): 208–17. https://doi.org/10.1215/S1152851703000577.
Merrill MK, Bernhardt G, Sampson JH, Wikstrand CJ, Bigner DD, Gromeier M. Poliovirus receptor CD155-targeted oncolysis of glioma. Neuro Oncol. 2004 Jul;6(3):208–17.
Merrill, Melinda K., et al. “Poliovirus receptor CD155-targeted oncolysis of glioma.Neuro Oncol, vol. 6, no. 3, July 2004, pp. 208–17. Pubmed, doi:10.1215/S1152851703000577.
Merrill MK, Bernhardt G, Sampson JH, Wikstrand CJ, Bigner DD, Gromeier M. Poliovirus receptor CD155-targeted oncolysis of glioma. Neuro Oncol. 2004 Jul;6(3):208–217.
Journal cover image

Published In

Neuro Oncol

DOI

ISSN

1522-8517

Publication Date

July 2004

Volume

6

Issue

3

Start / End Page

208 / 217

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Spinal Cord
  • Rhinovirus
  • Receptors, Virus
  • Poliovirus
  • Oncology & Carcinogenesis
  • Membrane Proteins
  • Humans
  • Glioma
  • Gene Expression Regulation, Viral