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Intergeneric poliovirus recombinants for the treatment of malignant glioma.

Publication ,  Journal Article
Gromeier, M; Lachmann, S; Rosenfeld, MR; Gutin, PH; Wimmer, E
Published in: Proc Natl Acad Sci U S A
June 6, 2000

Poliovirus neuropathogenicity depends on sequences within the 5' nontranslated region of the virus. Exchange of the poliovirus internal ribosomal entry site with its counterpart from human rhinovirus type 2 resulted in attenuation of neurovirulence in primates. Despite deficient virus propagation in cells of neuronal origin, nonpathogenic polio recombinants retain excellent growth characteristics in cell lines derived from glial neoplasms. Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. Intergeneric polio recombinants with heterologous internal ribosomal entry site elements unfolded strong oncolytic potential against experimentally induced gliomas in athymic mice. Our observations suggest that highly attenuated poliovirus recombinants may have applicability as biotherapeutic antineoplastic agents.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

June 6, 2000

Volume

97

Issue

12

Start / End Page

6803 / 6808

Location

United States

Related Subject Headings

  • Virus Replication
  • Tumor Cells, Cultured
  • Transplantation, Heterologous
  • Rhinovirus
  • Receptors, Virus
  • Poliovirus
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Membrane Proteins
 

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Gromeier, M., Lachmann, S., Rosenfeld, M. R., Gutin, P. H., & Wimmer, E. (2000). Intergeneric poliovirus recombinants for the treatment of malignant glioma. Proc Natl Acad Sci U S A, 97(12), 6803–6808. https://doi.org/10.1073/pnas.97.12.6803
Gromeier, M., S. Lachmann, M. R. Rosenfeld, P. H. Gutin, and E. Wimmer. “Intergeneric poliovirus recombinants for the treatment of malignant glioma.Proc Natl Acad Sci U S A 97, no. 12 (June 6, 2000): 6803–8. https://doi.org/10.1073/pnas.97.12.6803.
Gromeier M, Lachmann S, Rosenfeld MR, Gutin PH, Wimmer E. Intergeneric poliovirus recombinants for the treatment of malignant glioma. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6803–8.
Gromeier, M., et al. “Intergeneric poliovirus recombinants for the treatment of malignant glioma.Proc Natl Acad Sci U S A, vol. 97, no. 12, June 2000, pp. 6803–08. Pubmed, doi:10.1073/pnas.97.12.6803.
Gromeier M, Lachmann S, Rosenfeld MR, Gutin PH, Wimmer E. Intergeneric poliovirus recombinants for the treatment of malignant glioma. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6803–6808.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

June 6, 2000

Volume

97

Issue

12

Start / End Page

6803 / 6808

Location

United States

Related Subject Headings

  • Virus Replication
  • Tumor Cells, Cultured
  • Transplantation, Heterologous
  • Rhinovirus
  • Receptors, Virus
  • Poliovirus
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Membrane Proteins