Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.

Journal Article (Journal Article)

In many respects, picornaviruses are well suited for their proposed use as immunization vectors. However, their inherent genetic instability hinders application for prophylactic purposes. We demonstrate the improved expression and stability of a heterologous insert through a novel vector design strategy that partially replaces noncoding regulatory sequences with coding sequences for foreign gene products.

Full Text

Duke Authors

Cited Authors

  • Dufresne, AT; Dobrikova, EY; Schmidt, S; Gromeier, M

Published Date

  • September 2002

Published In

Volume / Issue

  • 76 / 17

Start / End Page

  • 8966 - 8972

PubMed ID

  • 12163617

Pubmed Central ID

  • PMC136971

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.76.17.8966-8972.2002


  • eng

Conference Location

  • United States