Mechanism of injury-provoked poliomyelitis.
Published
Journal Article
Skeletal muscle injury is known to predispose its sufferers to neurological complications of concurrent poliovirus infections. This phenomenon, labeled "provocation poliomyelitis," continues to cause numerous cases of childhood paralysis due to the administration of unnecessary injections to children in areas where poliovirus is endemic. Recently, it has been reported that intramuscular injections may also increase the likelihood of vaccine-associated paralytic poliomyelitis in recipients of live attenuated poliovirus vaccines. We have studied this important risk factor for paralytic polio in an animal system for poliomyelitis and have determined the pathogenic mechanism linking intramuscular injections and provocation poliomyelitis. Skeletal muscle injury induces retrograde axonal transport of poliovirus and thereby facilitates viral invasion of the central nervous system and the progression of spinal cord damage. The pathogenic mechanism of provocation poliomyelitis may differ from that of polio acquired in the absence of predisposing factors.
Full Text
Duke Authors
Cited Authors
- Gromeier, M; Wimmer, E
Published Date
- June 1998
Published In
Volume / Issue
- 72 / 6
Start / End Page
- 5056 - 5060
PubMed ID
- 9573275
Pubmed Central ID
- 9573275
International Standard Serial Number (ISSN)
- 0022-538X
Digital Object Identifier (DOI)
- 10.1128/JVI.72.6.5056-5060.1998
Language
- eng
Conference Location
- United States