Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction.

Journal Article (Journal Article;Review)

The ability of a virus to attach to a susceptible host cell is of utmost importance for the initiation of viral life cycle. Cell surface proteins called viral receptors mediate the initial steps of virus attachment and uptake. Poliovirus (PV) is one of the most studied animal viruses and its interaction with its cellular receptor, the human poliovirus receptor (hPVR) has been well characterized. This review will present our current understanding of the PV/hPVR interaction at the genetic and biochemical level. In addition, we will also discuss the implications of the PV/hPVR interaction on PV tissue tropism and the evolution of the three PV serotypes.

Full Text

Duke Authors

Cited Authors

  • Solecki, D; Gromeier, M; Harber, J; Bernhardt, G; Wimmer, E

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 11 / 1-6

Start / End Page

  • 2 - 9

PubMed ID

  • 10076797

International Standard Serial Number (ISSN)

  • 0952-3499

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1099-1352(199812)11:1/6<2::AID-JMR380>3.0.CO;2-D


  • eng

Conference Location

  • England