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Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors.

Publication ,  Journal Article
Zennadi, R; De Castro, L; Eyler, C; Xu, K; Ko, M; Telen, MJ
Published in: Transfus Clin Biol
2008

Erythrocytes containing primarily hemoglobin S (SS RBCs) are abnormally adherent. We now know that SS RBCs express numerous adhesion molecules, and that many of these can undergo activation. SS RBCs exposed briefly to epinephrine show markedly increased adhesion to both laminin and endothelial cells. In vivo, infusion of epinephrine-activated but not unstimulated SS RBCs causes RBC adhesion, vaso-occlusion, organ trapping, and shortened RBC survival in the circulation. Epinephrine treatment of SS RBCs before infusion also induces adhesion of murine leukocytes to vascular walls. Indeed, in vitro, SS RBCs can activate leukocyte adhesion and cytokine production. We now have demonstrated both in vitro and in vivo evidence for the importance of RBC signaling and have also shown that SS RBC adhesion is determined by genetic polymorphisms in the signaling pathway that activates adhesion. These advances will hopefully lead to new therapeutic modalities for sickle cell disease.

Duke Scholars

Published In

Transfus Clin Biol

DOI

ISSN

1246-7820

Publication Date

2008

Volume

15

Issue

1-2

Start / End Page

23 / 28

Location

France

Related Subject Headings

  • Signal Transduction
  • Polymorphism, Genetic
  • Mice
  • Leukocytes
  • Laminin
  • Humans
  • Erythrocytes
  • Endothelial Cells
  • Cell Adhesion Molecules
  • Cell Adhesion
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zennadi, R., De Castro, L., Eyler, C., Xu, K., Ko, M., & Telen, M. J. (2008). Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. Transfus Clin Biol, 15(1–2), 23–28. https://doi.org/10.1016/j.tracli.2008.04.009
Zennadi, R., L. De Castro, C. Eyler, K. Xu, M. Ko, and M. J. Telen. “Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors.Transfus Clin Biol 15, no. 1–2 (2008): 23–28. https://doi.org/10.1016/j.tracli.2008.04.009.
Zennadi R, De Castro L, Eyler C, Xu K, Ko M, Telen MJ. Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. Transfus Clin Biol. 2008;15(1–2):23–8.
Zennadi, R., et al. “Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors.Transfus Clin Biol, vol. 15, no. 1–2, 2008, pp. 23–28. Pubmed, doi:10.1016/j.tracli.2008.04.009.
Zennadi R, De Castro L, Eyler C, Xu K, Ko M, Telen MJ. Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. Transfus Clin Biol. 2008;15(1–2):23–28.
Journal cover image

Published In

Transfus Clin Biol

DOI

ISSN

1246-7820

Publication Date

2008

Volume

15

Issue

1-2

Start / End Page

23 / 28

Location

France

Related Subject Headings

  • Signal Transduction
  • Polymorphism, Genetic
  • Mice
  • Leukocytes
  • Laminin
  • Humans
  • Erythrocytes
  • Endothelial Cells
  • Cell Adhesion Molecules
  • Cell Adhesion