beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion.

Published

Journal Article

Sickle red cell (SS RBC) adhesion is thought to contribute to sickle cell disease (SCD) pathophysiology. SS RBC adhesion to laminin increases in response to adrenaline stimulation of beta(2)-adrenergic receptors (beta(2)ARs) and adenylate cyclase (ADCY6), and previous evidence suggests such activation occurs in vivo. We explored whether polymorphisms of the beta(2)AR and ADCY6 genes (ADRB2 and ADCY6, respectively) affect RBC adhesion to laminin. We found that the beta(2)AR arg(16)-->gly substitution and two non-coding ADCY6 polymorphisms were associated with elevated adhesion. We postulate that ADRB2 and ADCY6 polymorphisms may influence SCD severity through the mechanism of RBC adhesion.

Full Text

Duke Authors

Cited Authors

  • Eyler, CE; Jackson, T; Elliott, LE; De Castro, LM; Jonassaint, J; Ashley-Koch, A; Telen, MJ

Published Date

  • April 2008

Published In

Volume / Issue

  • 141 / 1

Start / End Page

  • 105 - 108

PubMed ID

  • 18324973

Pubmed Central ID

  • 18324973

Electronic International Standard Serial Number (EISSN)

  • 1365-2141

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2141.2008.07008.x

Language

  • eng

Conference Location

  • England