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Regulatory mechanisms that govern nicotinic synapse formation in neurons.

Publication ,  Journal Article
Rosenberg, MM; Blitzblau, RC; Olsen, DP; Jacob, MH
Published in: J Neurobiol
December 2002

Individual cholinoceptive neurons express high levels of different neuronal nicotinic acetylcholine receptor (nAChR) subtypes, and target them to the appropriate synaptic regions for proper function. This review focuses on the intercellular and intracellular processes that regulate nAChR expression in vertebrate peripheral nervous system (PNS) and central nervous system (CNS) neurons. Specifically, we discuss the cellular and molecular mechanisms that govern the induction and maintenance of nAChR expression-innervation, target tissue interactions, soluble factors, and activity. We define the regulatory principles of interneuronal nicotinic synapse differentiation that have emerged from these studies. We also discuss the molecular players that target nAChRs to the surface membrane and the interneuronal synapse.

Duke Scholars

Published In

J Neurobiol

DOI

ISSN

0022-3034

Publication Date

December 2002

Volume

53

Issue

4

Start / End Page

542 / 555

Location

United States

Related Subject Headings

  • Synapses
  • Receptors, Nicotinic
  • Neurons
  • Neurology & Neurosurgery
  • Humans
  • Animals
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1116 Medical Physiology
  • 1109 Neurosciences
 

Citation

APA
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ICMJE
MLA
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Rosenberg, M. M., Blitzblau, R. C., Olsen, D. P., & Jacob, M. H. (2002). Regulatory mechanisms that govern nicotinic synapse formation in neurons. J Neurobiol, 53(4), 542–555. https://doi.org/10.1002/neu.10112
Rosenberg, Madelaine M., Rachel C. Blitzblau, Douglas P. Olsen, and Michele H. Jacob. “Regulatory mechanisms that govern nicotinic synapse formation in neurons.J Neurobiol 53, no. 4 (December 2002): 542–55. https://doi.org/10.1002/neu.10112.
Rosenberg MM, Blitzblau RC, Olsen DP, Jacob MH. Regulatory mechanisms that govern nicotinic synapse formation in neurons. J Neurobiol. 2002 Dec;53(4):542–55.
Rosenberg, Madelaine M., et al. “Regulatory mechanisms that govern nicotinic synapse formation in neurons.J Neurobiol, vol. 53, no. 4, Dec. 2002, pp. 542–55. Pubmed, doi:10.1002/neu.10112.
Rosenberg MM, Blitzblau RC, Olsen DP, Jacob MH. Regulatory mechanisms that govern nicotinic synapse formation in neurons. J Neurobiol. 2002 Dec;53(4):542–555.
Journal cover image

Published In

J Neurobiol

DOI

ISSN

0022-3034

Publication Date

December 2002

Volume

53

Issue

4

Start / End Page

542 / 555

Location

United States

Related Subject Headings

  • Synapses
  • Receptors, Nicotinic
  • Neurons
  • Neurology & Neurosurgery
  • Humans
  • Animals
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1116 Medical Physiology
  • 1109 Neurosciences