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Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy.

Publication ,  Journal Article
Koontz, BF; Das, S; Temple, K; Bynum, S; Catalano, S; Koontz, JI; Montana, GS; Oleson, JR
Published in: Med Dosim
2009

Adjuvant radiotherapy for locally advanced prostate cancer improves biochemical and clinical disease-free survival. While comparisons in intact prostate cancer show a benefit for intensity modulated radiation therapy (IMRT) over 3D conformal planning, this has not been studied for post-prostatectomy radiotherapy (RT). This study compares normal tissue and target dosimetry and radiobiological modeling of IMRT vs. 3D conformal planning in the postoperative setting. 3D conformal plans were designed for 15 patients who had been treated with IMRT planning for salvage post-prostatectomy RT. The same computed tomography (CT) and target/normal structure contours, as well as prescription dose, was used for both IMRT and 3D plans. Normal tissue complication probabilities (NTCPs) were calculated based on the dose given to the bladder and rectum by both plans. Dose-volume histogram and NTCP data were compared by paired t-test. Bladder and rectal sparing were improved with IMRT planning compared to 3D conformal planning. The volume of the bladder receiving at least 75% (V75) and 50% (V50) of the dose was significantly reduced by 28% and 17%, respectively (p = 0.002 and 0.037). Rectal dose was similarly reduced, V75 by 33% and V50 by 17% (p = 0.001 and 0.004). While there was no difference in the volume of rectum receiving at least 65 Gy (V65), IMRT planning significant reduced the volume receiving 40 Gy or more (V40, p = 0.009). Bladder V40 and V65 were not significantly different between planning modalities. Despite these dosimetric differences, there was no significant difference in the NTCP for either bladder or rectal injury. IMRT planning reduces the volume of bladder and rectum receiving high doses during post-prostatectomy RT. Because of relatively low doses given to the bladder and rectum, there was no statistically significant improvement in NTCP between the 3D conformal and IMRT plans.

Duke Scholars

Published In

Med Dosim

DOI

EISSN

1873-4022

Publication Date

2009

Volume

34

Issue

3

Start / End Page

256 / 260

Location

United States

Related Subject Headings

  • Whole-Body Counting
  • Radiotherapy, Conformal
  • Radiotherapy, Adjuvant
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Prostatic Neoplasms
  • Organ Specificity
  • Oncology & Carcinogenesis
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Koontz, B. F., Das, S., Temple, K., Bynum, S., Catalano, S., Koontz, J. I., … Oleson, J. R. (2009). Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy. Med Dosim, 34(3), 256–260. https://doi.org/10.1016/j.meddos.2008.10.005
Koontz, Bridget F., Shiva Das, Kathy Temple, Sigrun Bynum, Suzanne Catalano, Jason I. Koontz, Gustavo S. Montana, and James R. Oleson. “Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy.Med Dosim 34, no. 3 (2009): 256–60. https://doi.org/10.1016/j.meddos.2008.10.005.
Koontz BF, Das S, Temple K, Bynum S, Catalano S, Koontz JI, et al. Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy. Med Dosim. 2009;34(3):256–60.
Koontz, Bridget F., et al. “Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy.Med Dosim, vol. 34, no. 3, 2009, pp. 256–60. Pubmed, doi:10.1016/j.meddos.2008.10.005.
Koontz BF, Das S, Temple K, Bynum S, Catalano S, Koontz JI, Montana GS, Oleson JR. Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy. Med Dosim. 2009;34(3):256–260.
Journal cover image

Published In

Med Dosim

DOI

EISSN

1873-4022

Publication Date

2009

Volume

34

Issue

3

Start / End Page

256 / 260

Location

United States

Related Subject Headings

  • Whole-Body Counting
  • Radiotherapy, Conformal
  • Radiotherapy, Adjuvant
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Prostatic Neoplasms
  • Organ Specificity
  • Oncology & Carcinogenesis
  • Male
  • Humans