In vivo cytokine-associated responses to biomaterials.

Journal Article (Journal Article)

Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1alpha, IL-2, IL-6, IL-1beta, VEGF, IL-4, and IL-10 were measured from exudate samples collected from cages containing specimens of polyethylene (PE), polyurethane (PU), or organotin polyvinyl chloride (ot-PVC). Empty cages served as negative controls, and lipopolysaccharide (LPS) served as a positive control. Cytokine, chemokine, and growth factor concentrations decreased from the time of implantation to eight weeks post-implantation, and there was an overall increase in cytokine, chemokine, and growth factor production for material-containing cages compared to empty cages. However, cytokine production was only modestly affected by the different surface chemistries of the three implanted polymeric materials.

Full Text

Duke Authors

Cited Authors

  • Schutte, RJ; Xie, L; Klitzman, B; Reichert, WM

Published Date

  • January 2009

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 160 - 168

PubMed ID

  • 18849070

Pubmed Central ID

  • PMC2621303

Electronic International Standard Serial Number (EISSN)

  • 1878-5905

Digital Object Identifier (DOI)

  • 10.1016/j.biomaterials.2008.09.026


  • eng

Conference Location

  • Netherlands