Radiation dose-volume effects of optic nerves and chiasm.

Journal Article (Journal Article;Review)

Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.

Full Text

Duke Authors

Cited Authors

  • Mayo, C; Martel, MK; Marks, LB; Flickinger, J; Nam, J; Kirkpatrick, J

Published Date

  • March 1, 2010

Published In

Volume / Issue

  • 76 / 3 Suppl

Start / End Page

  • S28 - S35

PubMed ID

  • 20171514

Electronic International Standard Serial Number (EISSN)

  • 1879-355X

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2009.07.1753


  • eng

Conference Location

  • United States