Predictors of wheezing in prematurely born children.

Journal Article (Journal Article)


To examine the degree to which neonatal illness severity, postneonatal health problems, child characteristics, parenting quality as measured by the HOME Inventory, and maternal characteristics are related to the development of wheezing in prematurely born children over the first 27 months after term.


Longitudinal predictive study.


Infants were recruited from two neonatal intensive care units, one in southeast and one in Midwest.


One hundred thirteen preterm infants who weighed less than 1,500 g or required mechanical ventilation and their mothers.

Main outcome measures

The presence of wheezing was obtained from maternal report at 2, 6, 9, 13, 18, 22, and 27 months. Wheezing was considered to be medically significant if the child was using bronchodilators or pulmonary antiinflammatory medications.


Sixty-eight percent of the children had wheezing at least one or more ages; 47% of the children were also taking bronchodilators or pulmonary antiinflammatory medications and thus had medically significant wheezing.


Postneonatal health problems and the social environment appear to be more important in developing wheezing in prematurely born children than neonatal medical complications.

Full Text

Duke Authors

Cited Authors

  • Holditch-Davis, D; Merrill, P; Schwartz, T; Scher, M

Published Date

  • May 2008

Published In

Volume / Issue

  • 37 / 3

Start / End Page

  • 262 - 273

PubMed ID

  • 18507597

Pubmed Central ID

  • PMC2709492

Electronic International Standard Serial Number (EISSN)

  • 1552-6909

International Standard Serial Number (ISSN)

  • 0884-2175

Digital Object Identifier (DOI)

  • 10.1111/j.1552-6909.2008.00238.x


  • eng