Giant cell interstitial pneumonia associated with nitrofurantoin.

Journal Article (Journal Article)

A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper/suppressor ratio in the bronchoalveolar lavage fluid (BALF). Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome.

Full Text

Duke Authors

Cited Authors

  • Hargett, CW; Sporn, TA; Roggli, VL; Hollingsworth, JW

Published Date

  • 2006

Published In

Volume / Issue

  • 184 / 3

Start / End Page

  • 147 - 149

PubMed ID

  • 16902839

International Standard Serial Number (ISSN)

  • 0341-2040

Digital Object Identifier (DOI)

  • 10.1007/s00408-005-2574-z


  • eng

Conference Location

  • United States