Giant cell tumor of rib masquerading as thymoma: a diagnostic pitfall in needle core biopsy of the mediastinum.


Journal Article

Giant cell tumor of bone is rarely seen in the rib, where it may present as a mediastinal mass. The diagnosis of giant cell tumor of bone is generally straightforward by fine-needle aspiration or needle core biopsy, but sampling problems may lead to confusion with other neoplasms or inflammatory processes. Here, we report a case of giant cell tumor of rib presenting as a mediastinal mass in a 36-year-old man. Because of inadequate sampling and inaccurate clinical information, the tumor was initially mistaken for thymoma. When the mass failed to respond to conventional chemotherapy, additional tissue was obtained and a giant cell tumor was diagnosed. Consequently, definitive therapy was delayed. The case illustrates an important diagnostic pitfall in the biopsy of mediastinal masses.

Full Text

Duke Authors

Cited Authors

  • Volmar, KE; Sporn, TA; Toloza, EM; Martinez, S; Dodd, LG; Xie, HB

Published Date

  • April 2004

Published In

Volume / Issue

  • 128 / 4

Start / End Page

  • 452 - 455

PubMed ID

  • 15043459

Pubmed Central ID

  • 15043459

Electronic International Standard Serial Number (EISSN)

  • 1543-2165

Digital Object Identifier (DOI)

  • 10.1043/1543-2165(2004)128<452:GCTORM>2.0.CO;2


  • eng

Conference Location

  • United States