Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.
Journal Article (Journal Article)
INTRODUCTION: The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting of a (131)I-labeled monoclonal antibody (mAb) injected into surgically created resection cavities during brain tumor resections. METHODS: Directed tissue samples of the cavity walls were obtained because of suspected tumor recurrence from 28 patients. Samples and clinical follow-up were evaluated on all patients (Group A) based on total radiation dose received and a subset of these (n=18; Group B, proximal therapy subset) who had received external beam therapy within
Full Text
Duke Authors
- Bigner, Darell Doty
- Friedman, Allan Howard
- Friedman, Henry Seth
- Herndon II, James Emmett
- McLendon, Roger Edwin
- Zalutsky, Michael Rod
Cited Authors
- McLendon, RE; Akabani, G; Friedman, HS; Reardon, DA; Cleveland, L; Cokgor, I; Herndon, JE; Wikstrand, C; Boulton, ST; Friedman, AH; Bigner, DD; Zalutsky, MR
Published Date
- May 2007
Published In
Volume / Issue
- 34 / 4
Start / End Page
- 405 - 413
PubMed ID
- 17499730
Pubmed Central ID
- PMC1952684
International Standard Serial Number (ISSN)
- 0969-8051
Digital Object Identifier (DOI)
- 10.1016/j.nucmedbio.2007.01.009
Language
- eng
Conference Location
- United States