Mutant metabolic enzymes are at the origin of gliomas.


Journal Article (Review)

Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.

Full Text

Duke Authors

Cited Authors

  • Yan, H; Bigner, DD; Velculescu, V; Parsons, DW

Published Date

  • December 15, 2009

Published In

Volume / Issue

  • 69 / 24

Start / End Page

  • 9157 - 9159

PubMed ID

  • 19996293

Pubmed Central ID

  • 19996293

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-09-2650


  • eng

Conference Location

  • United States